https://www.teamtrio.org/news-mentor daily 0.75 2023-10-06 https://www.teamtrio.org/news-mentor/2021/9/3/meet-leo monthly 0.5 2023-04-05 https://images.squarespace-cdn.com/content/v1/5afdd8cd5417fc156919f0f5/1630703128449-MWT6ML16OLVU54E7HVUA/Leo2.jpg Meet TRIO Families - meet LEO - Metti in risalto Leo https://www.teamtrio.org/news-mentor/2016/eu-scelerisque-nisi-vehicula-x5n6r-2fp46 monthly 0.5 2023-04-05 https://images.squarespace-cdn.com/content/v1/5afdd8cd5417fc156919f0f5/1622562397848-9LLLRJ0UA0135C0SBTEB/Haisley.jpg Meet TRIO Families - Meet Haisley Jean Haisley Jean https://www.teamtrio.org/news-mentor/delilah monthly 0.5 2023-04-05 https://images.squarespace-cdn.com/content/v1/5afdd8cd5417fc156919f0f5/1621265843344-4MIEB2V3EA9ALHV8IENG/Screen+Shot+2021-05-17+at+11.35.48.png Meet TRIO Families - Meet Delilah - Make it stand out Delilah https://www.teamtrio.org/news-mentor/saoirse monthly 0.5 2023-04-05 https://images.squarespace-cdn.com/content/v1/5afdd8cd5417fc156919f0f5/1621265757052-9AJ6TU5CNUL3Y1H7WE2A/Screen+Shot+2021-05-17+at+11.35.40.png Meet TRIO Families - Meet Saoirse - Make it stand out Saoirse https://www.teamtrio.org/news-mentor/nixon monthly 0.5 2023-04-05 https://images.squarespace-cdn.com/content/v1/5afdd8cd5417fc156919f0f5/1622493626429-57OJMR57MUCMSDIJN3A2/nixon.jpg Meet TRIO Families - Meet Nixon - Make it stand out Nixon https://www.teamtrio.org/news-mentor/2016/eu-scelerisque-nisi-vehicula-x5n6r monthly 0.5 2023-04-05 https://images.squarespace-cdn.com/content/v1/5afdd8cd5417fc156919f0f5/1619792535926-LOXG3EDNFQ5B20AN7KQU/140342536_10219600937038613_2767191924540139722_n.jpg Meet TRIO Families - Meet Chase Chase https://www.teamtrio.org/news-mentor/category/Category+1 monthly 0.5 https://www.teamtrio.org/about daily 0.75 2021-10-19 https://www.teamtrio.org/home-mentor daily 1.0 2025-12-23 https://images.squarespace-cdn.com/content/v1/5afdd8cd5417fc156919f0f5/1634506701740-24OM3YUJ5YF2NEQT5TFN/unsplash-image-lQGJCMY5qcM.jpg Home - Research opportunities https://images.squarespace-cdn.com/content/v1/5afdd8cd5417fc156919f0f5/1634507753532-20JTAGSOMJU02WZTRXIV/GettyImages-1165058710.jpg Home - TRIO gene mutation https://images.squarespace-cdn.com/content/v1/5afdd8cd5417fc156919f0f5/1748359162072-M6QBPD7OS89SPFPOOUB1/unsplash-image-gxD8hCmi0IQ.jpg Home - Contact us https://images.squarespace-cdn.com/content/v1/5afdd8cd5417fc156919f0f5/1634506633316-4T50HL0WTGNGKIB8M6NR/unsplash-image-Mb-RH_Kz0jo.jpg Home - Newly diagnosed https://images.squarespace-cdn.com/content/v1/5afdd8cd5417fc156919f0f5/421c3bfb-4883-4908-97cc-882d012d5b17/unsplash-image-smgTvepind4.jpg Home - Our Community We would like to help families by offering them the opportunity to meet each other by joining our Community. In a community we understand each other, help each other, advise each other and fight together for the future of our families and those that will join us in the future. If you or a loved one is affected by the TRIO gene mutation, please join our community on Facebook. https://images.squarespace-cdn.com/content/v1/5afdd8cd5417fc156919f0f5/1619791549689-1DG7UHD7JAINL3RPRPDK/solid-ecae6b-2500x1667.jpg Home - Team TRIO Learn More → https://images.squarespace-cdn.com/content/v1/5afdd8cd5417fc156919f0f5/1633298926100-OQVFRFW75SGU58BOPE2Q/unsplash-image-ry_sD0P1ZL0.jpg Home https://images.squarespace-cdn.com/content/v1/5afdd8cd5417fc156919f0f5/1644182681642-6MQFGG3DAIT08HX6SP13/unsplash-image-8o_LkMpo8ug.jpg Home https://www.teamtrio.org/nuovo-blog daily 0.75 2023-04-05 https://www.teamtrio.org/merlos-lab daily 0.75 2023-07-14 https://www.teamtrio.org/meetresearchers daily 0.75 2024-09-11 https://www.teamtrio.org/meetresearchers/2023/10/30/crowfunding-campaign-for-trio-research monthly 0.5 2023-11-14 https://www.teamtrio.org/trio-gene-mutation daily 0.75 2018-05-19 https://www.teamtrio.org/whatistrio daily 0.75 2025-12-23 https://images.squarespace-cdn.com/content/v1/5afdd8cd5417fc156919f0f5/1637081306464-RARUCG08ZRZ8D7JACSQT/unsplash-image-NFvdKIhxYlU.jpg Trio Gene Mutation https://images.squarespace-cdn.com/content/v1/5afdd8cd5417fc156919f0f5/a2b92760-2bea-4eb8-863d-8ec84597ee1e/from+the+community.png Trio Gene Mutation - Metti in risalto Di qualunque cosa si tratti, il modo in cui racconti la tua storia online può fare la differenza. https://images.squarespace-cdn.com/content/v1/5afdd8cd5417fc156919f0f5/1633637683296-IXODBUGNBJLA24R8PW1N/unsplash-image-V106bb1a9BY.jpg Trio Gene Mutation https://images.squarespace-cdn.com/content/v1/5afdd8cd5417fc156919f0f5/d3775d8a-c07a-45ad-bb83-20a43547c76e/Chart.png Trio Gene Mutation Visual representation of the growth of TRIO cases within the Team TRIO community over the years. https://images.squarespace-cdn.com/content/v1/5afdd8cd5417fc156919f0f5/1633637721885-PZRK65FSK9IV44L3UOCJ/unsplash-image-gEKMstKfZ6w.jpg Trio Gene Mutation https://www.teamtrio.org/contact-mentor daily 0.75 2025-12-23 https://www.teamtrio.org/start-here daily 0.75 2023-08-01 https://images.squarespace-cdn.com/content/v1/5afdd8cd5417fc156919f0f5/1633640808665-LNRTGZ80PHH8H78X7HXI/unsplash-image-G_XEVKf3eTU.jpg Newly Diagnosed - Join us! If your child has been diagnosed with TRIO gene mutation syndrome, please see the contact page and reach out to us soon. https://www.teamtrio.org/terms-conditions daily 0.75 2021-05-17 https://www.teamtrio.org/privacy-policy daily 0.75 2021-05-17 https://www.teamtrio.org/bibliography daily 0.75 2023-08-01 https://www.teamtrio.org/search-page daily 0.75 2021-10-01 https://www.teamtrio.org/research-1 daily 0.75 2023-03-26 https://images.squarespace-cdn.com/content/v1/5afdd8cd5417fc156919f0f5/1621264790295-6UD2B1B058UDETSL9QZO/unnamed-1.png Research - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5afdd8cd5417fc156919f0f5/1629753439598-ARQH3BGU039ARXA7BNYL/SS.png Research - Metti in risalto Di qualunque cosa si tratti, il modo in cui racconti la tua storia online può fare la differenza. https://images.squarespace-cdn.com/content/v1/5afdd8cd5417fc156919f0f5/3840aaf1-0adc-49fd-b135-8c9b0a1ac4ec/logo+genida.jpg Research - Metti in risalto Di qualunque cosa si tratti, il modo in cui racconti la tua storia online può fare la differenza. https://www.teamtrio.org/conference daily 0.75 2024-08-02 https://images.squarespace-cdn.com/content/v1/5afdd8cd5417fc156919f0f5/dfab96f1-2cd7-4eef-bb0d-42d172b67a31/Picture9.png Conference - Various studies report that many neuropsychiatric disorders are characterized by dendritic and synaptic pathology, including abnormal spine density and morphology, synapse loss, and aberrant synaptic signaling and plasticity. Koleske´s lab is focused in identifying players that control dendrite and synapse development and elucidate the mechanisms by which they function. https://images.squarespace-cdn.com/content/v1/5afdd8cd5417fc156919f0f5/3e7923da-f8c8-4390-9fb2-976d9f003966/kate-baker.jpg Conference - Dr. Kate Baker Programme Leader Track at the MRC Cognition and Brain Sciences Unit, University of Cambridge https://images.squarespace-cdn.com/content/v1/5afdd8cd5417fc156919f0f5/b3b1f411-77cb-4f72-a823-a5f37c943939/foto_01.jpg Conference https://images.squarespace-cdn.com/content/v1/5afdd8cd5417fc156919f0f5/5cc48f46-06e0-4934-9128-f739ccc27f5f/thony.png Conference - Anthony Koleske PhD, Professor, Molecular Biochemistry and Biophysics Yale University https://images.squarespace-cdn.com/content/v1/5afdd8cd5417fc156919f0f5/1667571834404-AN52Q5QXOSOXRX7241C3/unsplash-image-zD-N7Bje8Eg.jpg Conference - TRIO is essential for mouse development Therefore, mice are also used as a model system to study the effect of single mutations in the overall development. By using other model systems, researchers can obtain more and faster information about the impact of presenting an specific TRIO mutation. https://images.squarespace-cdn.com/content/v1/5afdd8cd5417fc156919f0f5/1653942261678-KK8X5ENZGUDE78MV4ANS/Paolo.png Conference - Paolo Mencherini - MSc Engineer - Technical Manager at Covestro Deutschland AG https://images.squarespace-cdn.com/content/v1/5afdd8cd5417fc156919f0f5/9e6b2fa6-9136-4206-9405-018aeece5f3e/Picture1.png Conference Please fill the online questionnaire to take part of this incredible program to find out how specific TRIO gene differences affect individual's Intellectual Disability (ID): https://www.mrc-cbu.cam.ac.uk/bingo Who can enrol? TRIO patients 3+ years https://images.squarespace-cdn.com/content/v1/5afdd8cd5417fc156919f0f5/cb71b8f4-67b0-45dc-83c8-8188276c6709/Picture12.png Conference - Prof. Merlo´s Team uses Human Pluripotent Stem Cells (iPSC) from rare patients through reprogramming or healthy patients through mutagenesis. From iPSC they can investigate and answer questions related to: - Proliferation; - Differentiation and morphology; - Network formation and electrical activity. https://images.squarespace-cdn.com/content/v1/5afdd8cd5417fc156919f0f5/35a74841-d66f-43b3-844e-1e0dc4421308/Jennifer.jpg Conference - Jennifer Hamilton - Canadian former Research Scientist - Biotechnology Venture capital - Business development in Big Pharma https://images.squarespace-cdn.com/content/v1/5afdd8cd5417fc156919f0f5/c0d13012-9308-4485-bdce-83fbfb7a9c7e/Baralle.png Conference - Diana Baralle MD Assoc. Dean (Research) Professor, Genomic Medicine https://images.squarespace-cdn.com/content/v1/5afdd8cd5417fc156919f0f5/0f8eb91b-4674-4690-a201-73a9ac81c434/Picture2.png Conference - TRIO gene controls axon outgrowth, guidance and synaptogenesis. https://images.squarespace-cdn.com/content/v1/5afdd8cd5417fc156919f0f5/6c84ffcc-db1f-4206-9568-2d532a4d0cb6/Picture3.png Conference - Synapse is the contact of two neurons and its very important for the transmission of information. In patients with intellectual disability (ID) and attention deficit disorder (ASD), the synaptic functions are altered. https://images.squarespace-cdn.com/content/v1/5afdd8cd5417fc156919f0f5/d7909727-5bb0-49e3-a7ec-dddfdbb9f820/Picture6.png Conference - Metti in risalto Di qualunque cosa si tratti, il modo in cui racconti la tua storia online può fare la differenza. https://images.squarespace-cdn.com/content/v1/5afdd8cd5417fc156919f0f5/b4228eda-1f2e-4ae7-9b5c-1606fad5de41/Picture8.png Conference - The pathogenicity of many TRIO mutations is uncertain. Herring´s research group is interested in identifying mutations that alter TRIO functions by a novel structure-based approach. This means, they can predict in silico (computer simulation) how certain mutations can modify TRIO function. https://images.squarespace-cdn.com/content/v1/5afdd8cd5417fc156919f0f5/b98b0ab6-81ab-4ed2-ab44-44ca1118f731/Picture4.png Conference - The remodeling of the neurons shape requires remodeling of the actin cytoskeleton that is regulated by a protein family, the Rho GTPases. TRIO is a RhoGEF, an activator of Rho GTPases and a major regulator of neurodevelopment. https://images.squarespace-cdn.com/content/v1/5afdd8cd5417fc156919f0f5/02117172-69f4-4207-b3a3-42baf239d47c/Gaby_2.png Conference - Gabriella Gazdagh Consultant, Clinical Genetics University of Southampton https://images.squarespace-cdn.com/content/v1/5afdd8cd5417fc156919f0f5/9d5132ac-7719-4531-9499-af7eb698b876/Picture10.png Conference - Metti in risalto Di qualunque cosa si tratti, il modo in cui racconti la tua storia online può fare la differenza. https://images.squarespace-cdn.com/content/v1/5afdd8cd5417fc156919f0f5/1774ef79-bf33-4e8e-9f8e-c05b8fce27ad/Picture5.png Conference - TRIO missense variants are found clustered into two main groups https://images.squarespace-cdn.com/content/v1/5afdd8cd5417fc156919f0f5/9e62bb22-459b-4d79-b072-e283dc933c11/Debant+Team.png Conference - Metti in risalto The DEBANT Research Team - CNRS Montpellier, FRANCE Present members: Pauline BOIROUX; Marion BONHOMME; Maxime BONNET; Jérôme BOUDEAU; Franck COMUNALE; Anne DEBANT; Aline HAETTY; Susanne SCHMIDT https://images.squarespace-cdn.com/content/v1/5afdd8cd5417fc156919f0f5/e5389d66-8f53-4502-96e9-31a57e0fd329/Xenopus_laevis_02.jpg Conference - Xenopus model Xenopus are also used as a model system to study the effect of single mutations in the overall development. By using other model systems, researchers can obtain more and faster information about the impact of presenting an specific TRIO mutation. https://images.squarespace-cdn.com/content/v1/5afdd8cd5417fc156919f0f5/bbbf56e3-a8f4-4a78-8232-ec91c061b186/bruce.jpeg Conference - Bruce Herring PhD, Assistant Professor, Neurobiology University of Southern California https://images.squarespace-cdn.com/content/v1/5afdd8cd5417fc156919f0f5/dcad9773-b136-459a-8f95-7166a22e6887/jun+li.png Conference - Jun Li Professor, Peking University Inst. Mental Health, Beijing China https://images.squarespace-cdn.com/content/v1/5afdd8cd5417fc156919f0f5/efd70b97-b0ca-45fb-b2dd-2c0f788542aa/Picture11.png Conference - TRIO GEF1-mediated signaling is essential and necessary for interneuron migration (IN) in a SDFɑ/CXCRA dependent manner. https://images.squarespace-cdn.com/content/v1/5afdd8cd5417fc156919f0f5/7a1bd575-c37d-4259-aa9c-4fbb77c4186f/merlo.png Conference - Metti in risalto Laboratorio di Genetica Molecolare del Neurosviluppo - Dipartimento di Biotecnologie Molecolari e Scienze per la Salute, Università di Torino. Members: Prof. Giorgio Roberto Merlo; Carla Liaci; Mattia Camera; Giovanni Caslini; Simona Rando; Lucia Prandi. https://images.squarespace-cdn.com/content/v1/5afdd8cd5417fc156919f0f5/a5d00493-c3a5-4097-820e-2b1eb721d0b0/Picture7.png Conference - The Rho guanine nucleotide exchange factor (RhoGEF) TRIO promotes actin polymerization by directly activating the small GTPase Rac1. Recent studies suggest that autism spectrum disorder (ASD)-related behavioral phenotypes in animal models of ASD can be produced by dysregulation of Rac1’s control of actin polymerization at glutamatergic synapses. Here, in humans, Herring and his team discovered a large cluster of ASD-related de novo mutations in Trio’s Rac1 activating domain, GEF1. https://www.teamtrio.org/2022-publications daily 0.75 2023-08-01 https://www.teamtrio.org/french-event daily 0.75 2024-08-02 https://www.teamtrio.org/interview_with_adult daily 0.75 2023-08-01 https://images.squarespace-cdn.com/content/v1/5afdd8cd5417fc156919f0f5/1671381038875-D5E8ZVSXGLWLKD711CAK/unsplash-image-ZtLASJerPb0.jpg Interview_with_adult “You can be successful. Be yourself. You can do this, you can live independently“ https://www.teamtrio.org/trio-one-pager daily 0.75 2023-08-01 https://images.squarespace-cdn.com/content/v1/5afdd8cd5417fc156919f0f5/d79e01d5-15e6-496d-bb45-538de203b878/one+pager.jpg TRIO one pager https://www.teamtrio.org/2023-publications daily 0.75 2024-01-11 https://www.teamtrio.org/bingo daily 0.75 2023-06-01 https://images.squarespace-cdn.com/content/v1/5afdd8cd5417fc156919f0f5/1685535138588-9HAXWS5CYW63VY6YLQCL/image-asset.jpeg BINGO - Metti in risalto Di qualunque cosa si tratti, il modo in cui racconti la tua storia online può fare la differenza. https://images.squarespace-cdn.com/content/v1/5afdd8cd5417fc156919f0f5/baa310a5-018d-45e5-bba1-fe17f665e0c9/CBSU6.png BINGO - Metti in risalto Di qualunque cosa si tratti, il modo in cui racconti la tua storia online può fare la differenza. https://images.squarespace-cdn.com/content/v1/5afdd8cd5417fc156919f0f5/60b84a3f-6cac-4841-8e39-bc1e8346796e/Picture.JPG BINGO “Thank you to all the young people and families who have taken part in previous BINGO project activities! We have observed a wide range of neurodevelopmental abilities and difficulties amongst individuals with a TRIO gene difference. We are now focusing on aspects of development such as visual function and communication, which may be particularly important for TRIO and related genes.“ Josefine Eck, Research Staff https://images.squarespace-cdn.com/content/v1/5afdd8cd5417fc156919f0f5/cecab29b-e172-43b4-b043-2d6ce63dd2e0/BINGO+logo.jpeg BINGO BINGO stands for Brain and Behaviour in Neurodevelopmental Disorders of Genetic Origin. https://www.teamtrio.org/merlo-s-lab daily 0.75 2024-10-15 https://images.squarespace-cdn.com/content/v1/5afdd8cd5417fc156919f0f5/37258fe4-4e91-42ee-bdd7-dccc4b6d9ef6/MErlo.png Merlo´s Lab - Metti in risalto Di qualunque cosa si tratti, il modo in cui racconti la tua storia online può fare la differenza. https://www.teamtrio.org/resources-1 daily 0.75 2024-09-11 https://images.squarespace-cdn.com/content/v1/5afdd8cd5417fc156919f0f5/1702301057337-A5R6K4P8EWKG7LVD8031/image-asset.jpeg Resources - Resources Open Sources Providing Information about TRIO Gene https://www.teamtrio.org/2032-news daily 0.75 2023-12-16 https://images.squarespace-cdn.com/content/v1/5afdd8cd5417fc156919f0f5/73ff6efe-f5db-4c3d-9d78-8abaac741c88/crescita+facebook+2023.png 2023_news - Metti in risalto Growth in the number of members in our facebook community from January 1 2023. https://images.squarespace-cdn.com/content/v1/5afdd8cd5417fc156919f0f5/1702482576112-0QAG7WGRNW8VY0P84VEL/image-asset.jpeg 2023_news - The power of diversity https://www.teamtrio.org/qa-report daily 0.75 2023-12-16 https://www.teamtrio.org/2024-publications daily 0.75 2024-09-23 https://images.squarespace-cdn.com/content/v1/5afdd8cd5417fc156919f0f5/1727090056608-7W24OPWORXGC038DK3W6/unsplash-image-gKUC4TMhOiY.jpg 2024 - Publications - 2024 PUBLICATIONS Chosen scientific publication for the year 2024 https://www.teamtrio.org/world-trio-day daily 0.75 2025-03-02 https://images.squarespace-cdn.com/content/v1/5afdd8cd5417fc156919f0f5/1740938051355-CHESORQ1ALW83K7PME54/Picture_01.png world trio day https://images.squarespace-cdn.com/content/v1/5afdd8cd5417fc156919f0f5/1740938051430-ST2BNWDU1X4LX9I0WJJU/Picture_02.png world trio day https://images.squarespace-cdn.com/content/v1/5afdd8cd5417fc156919f0f5/1740938052719-ETYY3P4GFYHLU6Z3QV97/Picture_03.png world trio day https://www.teamtrio.org/2025-publications daily 0.75 2025-12-23 https://images.squarespace-cdn.com/content/v1/5afdd8cd5417fc156919f0f5/1747998533273-05O5MT0I4H6G8WM1V1DF/unsplash-image-8StnO-aqV7o.jpg 2025 - Publications - 2025 PUBLICATIONS Chosen scientific publication for the year 2025 https://www.teamtrio.org/2025-international-conference daily 0.75 2025-12-17